Louisville Cardinals
| Date | Opponent | Result | YPP Gained | YPP Allowed | YPP Diff | YPP Win Prob | TO Margin |
|---|
| Aug 30August 30 | vs Eastern Kentucky (1-1) | W 51-17 | 8.09 | 2.83 | +5.26 | 100.00%
| -3 |
| Sep 5September 5 (Fri) | vs James Madison (1-1) | W 28-14 | 4.98 | 3.37 | +1.61 | 85.42%
| +1 |
| Sep 20September 20 | vs Bowling Green (1-1) | | | | | | |
| Sep 27September 27 | at Pittsburgh (2-0) | | | | | | |
| Oct 4October 4 | vs Virginia (1-1) | | | | | | |
| Oct 17October 17 (Fri) | at #5 Miami (2-0) | 7:00 PM | | | | | |
| Oct 25October 25 | vs Boston College (1-1) | | | | | | |
| Nov 1November 1 | at Virginia Tech (0-2) | | | | | | |
| Nov 8November 8 | vs California (2-0) | | | | | | |
| Nov 14November 14 (Fri) | vs #8 Clemson (1-1) | 8:00 PM | | | | | |
| Nov 22November 22 | at #17 SMU (1-1) | | | | | | |
| Nov 29November 29 | vs Kentucky (1-1, 0-1) | | | | | | |
| | Final Record | YPP Gained | YPP Allowed | YPP Diff | Expected Record | TO Margin |
|---|
| | 2-0 | 6.72 | 3.15 | +3.564 | 1.85-0.15 (+0.15) | -2 |