| Rank | Game Date | Opponent | Player | Carries | Rush Yards | Yards Per Carry | TD | Long |
|---|
| 1 | December 4, 1999 | Massachusetts | Adrian Peterson | 32 | 333 | 10.00 | 5 | 38 |
| 2 | December 1, 2012 | Central Arkansas | Jerick McKinnon | 34 | 316 | 9.00 | 2 | 57 |
| 3 | November 18, 1989 | Marshall | Joe Ross | 24 | 280 | 11.00 | 3 | 62 |
| 4 | November 3, 2007 | Wofford | Jayson Foster | 28 | 279 | 9.00 | 3 | 82 |
| 5 | December 3, 2011 | Old Dominion | Dominique Swope | 31 | 255 | 8.00 | 2 | 76 |
| 6 | September 15, 2007 | Coastal Carolina | Jayson Foster | 28 | 253 | 9.00 | 6 | 55 |
| 7 | December 18, 1999 | Youngstown State | Adrian Peterson | 25 | 247 | 9.00 | 3 | 58 |
| 8 | November 29, 1997 | Florida A&M | Greg Hill | 26 | 238 | 9.00 | 4 | 54 |
| 9 | December 5, 1998 | Connecticut | Adrian Peterson | 33 | 232 | 7.00 | 4 | 31 |
| 10 | October 24, 1998 | The Citadel | Adrian Peterson | 22 | 231 | 10.00 | 5 | 51 |
| 11 | September 8, 2007 | West Georgia | Jayson Foster | 11 | 231 | 21.00 | 3 | 74 |
| 12 | December 19, 1998 | Massachusetts | Greg Hill | 29 | 228 | 7.00 | 2 | 41 |
| 13 | September 25, 1999 | Chattanooga | Adrian Peterson | 21 | 222 | 10.00 | 4 | 60 |
| 14 | October 26, 1996 | The Citadel | Roderick Russell | 24 | 221 | 9.00 | 1 | 41 |
| 15 | September 26, 1998 | Chattanooga | Adrian Peterson | 29 | 221 | 7.00 | 4 | 47 |
| 16 | November 6, 1999 | Furman | Greg Hill | 28 | 219 | 7.00 | 1 | 41 |
| 17 | September 12, 1998 | Jacksonville State | Adrian Peterson | 21 | 219 | 10.00 | 4 | 45 |
| 18 | November 7, 1998 | Furman | Greg Hill | 19 | 219 | 11.00 | 4 | 57 |
| 19 | September 9, 2006 | Central Connecticut | Chris Covington | 29 | 216 | 7.00 | 1 | 30 |
| 20 | October 30, 1999 | East Tennessee State | Adrian Peterson | 33 | 216 | 6.00 | 4 | 34 |
| 21 | October 2, 2021 | Arkansas State | Logan Wright | 10 | 214 | 21.00 | 2 | 60 |
| 22 | October 2, 1999 | Virginia Military | Adrian Peterson | 23 | 211 | 9.00 | 3 | 35 |
| 23 | October 17, 1998 | Appalachian State | Adrian Peterson | 24 | 210 | 8.00 | 2 | 54 |
| 24 | November 15, 2014 | Navy | Matt Breida | 17 | 210 | 12.00 | 2 | 88 |
| 25 | September 22, 2007 | Chattanooga | Jayson Foster | 26 | 210 | 8.00 | 3 | 60 |
| 26 | October 31, 1998 | East Tennessee State | Adrian Peterson | 18 | 209 | 11.00 | 2 | 91 |
| 27 | October 4, 2003 | Florida International | Jermaine Austin | 33 | 207 | 6.00 | 1 | 35 |
| 28 | September 15, 2007 | Coastal Carolina | Lamar Lewis | 18 | 206 | 11.00 | 0 | 63 |
| 29 | October 29, 2015 | Texas State | Matt Breida | 23 | 205 | 8.00 | 2 | 48 |
| 30 | November 25, 2000 | McNeese State | Adrian Peterson | 19 | 203 | 10.00 | 1 | 53 |
| 31 | November 27, 1982 | Florida State JV | Melvin Bell | 20 | 201 | 10.00 | 1 | 74 |
| 32 | October 25, 2014 | Georgia State | Matt Breida | 12 | 201 | 16.00 | 4 | 75 |